Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual-patient data from six randomized clinical trials

نویسندگان

  • Peter M. Fayers
  • Antonio Palumbo
  • Cyrille Hulin
  • Anders Waage
  • Pierre Wijermans
  • Meral Beksaç
  • Sara Bringhen
  • Jean-Yves Mary
  • Peter Gimsing
  • Fabian Termorshuizen
  • Rauf Haznedar
  • Tommaso Caravita
  • Philippe Moreau
  • Ingemar Turesson
  • Pellegrino Musto
  • Lotfi Benboubker
  • Martijn Schaafsma
  • Pieter Sonneveld
  • Thierry Facon
  • Peter Fayers
چکیده

Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual-patient data from six randomized clinical trials Peter M. Fayers, Antonio Palumbo, Cyrille Hulin, Anders Waage, Pierre Wijermans, Meral Beksaç, Sara Bringhen, Jean-Yves Mary, Peter Gimsing, Fabian Termorshuizen, Rauf Haznedar, Tommaso Caravita, Philippe Moreau, Ingemar Turesson, Pellegrino Musto, Lotfi Benboubker, Martijn Schaafsma, Pieter Sonneveld, Thierry Facon on behalf of NMSG, GIMEMA, TMSG, HOVON, IFM, and European Myeloma Network. Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Divisione di Ematologia dell'Università di Torino, A.O.U. S. Giovanni Battista, Torino, Italy; Hematology Department, University Hospital, Nancy, France; Department of Hematology, St. Olavs University Hospital, Trondheim, Norway; Department of Hematology, Haga Hospital, The Hague, The Netherlands; Department of Hematology, Ankara University, Ankara, Turkey; Divisione di Ematologia dell'Università di Torino, A.O.U. S. Giovanni Battista, Torino, Italy; INSERM U717, Université Paris 7, Hôpital Saint-Louis, Paris, France; Department of Hematology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark; Erasmus Medical Center and University, Rotterdam, The Netherlands; Department of Hematology , Gazi University School of Medicine, Ankara, Turkey; Cattedra e Divisione di Ematologia, Università Tor Vergata, Ospedale S. Eugenio, Roma, Italy; Centre Hospitalier Universitaire, Nantes, France; Department of Hematology, Skane University Hospital, Malmö, Sweden; Department of Onco-Hematology, IRCCS "Centro di Riferimento Oncologico della Basilicata" Rionero in Vulture (Pz), Italy; Oncohématologie CHRU, Hôpital Bretonneau, Tours, France; Medical Spectrum Twente, Enschede, The Netherlands; Erasmus Medical Center and University, Rotterdam, The Netherlands; Department of Hematology, Hôpital Claude Huriez, Lille, France; Nordic Myeloma Study Group; Italian Multiple Myeloma Network; Turkish Myeloma Study Group; Hemato-Oncologie voor Volwassenen Nederland Intergroupe Francophone du Myélome.

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منابع مشابه

Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials.

The role of thalidomide for previously untreated elderly patients with multiple myeloma remains unclear. Six randomized controlled trials, launched in or after 2000, compared melphalan and prednisone alone (MP) and with thalidomide (MPT). The effect on overall survival (OS) varied across trials. We carried out a meta-analysis of the 1685 individual patients in these trials. The primary endpoint...

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A European strategy for targeted education in hematology.

et al. Multiple myeloma in elderly patients: presenting features and outcome. Eur J Haematol. 2001;66(1):11-7. 15. Palumbo A, Bringhen S, Caravita T, Merla E, Capparella V, Callea V, et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomized controlled trial. Lancet. 2006;367(9513):825-31....

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CLINICAL TRIALS AND OBSERVATIONS Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials

Peter M. Fayers,1,2 Antonio Palumbo,3 Cyrille Hulin,4 Anders Waage,2,5 Pierre Wijermans,6 Meral Beksaç,7 Sara Bringhen,8 Jean-Yves Mary,9 Peter Gimsing,10 Fabian Termorshuizen,11 Rauf Haznedar,12 Tommaso Caravita,13 Philippe Moreau,14 Ingemar Turesson,15 Pellegrino Musto,16 Lotfi Benboubker,17 Martijn Schaafsma,18 Pieter Sonneveld,19 and Thierry Facon,20 on behalf of the Nordic Myeloma Study Gr...

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Thalidomide-based Regimens for Elderly and/or Transplant Ineligible Patients with Multiple Myeloma: A Meta-analysis

BACKGROUND Thalidomide is an immunomodulatory and anti-angiogenic drug that has shown promise in patients with myeloma. Trials comparing efficacy of standard melphalan and prednisone (MP) therapy with MP plus thalidomide (MPT) in transplant-ineligible or elderly patients with multiple myeloma (MM) have provided conflicting evidence. This meta-analysis aimed to determine the efficacy and toxicit...

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Induction regimens for transplant-eligible patients with newly diagnosed multiple myeloma: a network meta-analysis of randomized controlled trials

OBJECTIVE The aim of this study was to compare the early efficacy and survivals of induction regimens for transplant-eligible patients with untreated multiple myeloma. MATERIALS AND METHODS A comprehensive literature search in electronic databases was conducted for relevant randomized controlled trials (RCTs). Eligible studies were selected according to the predefined selection criteria, befo...

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تاریخ انتشار 2011